{"id":11203,"date":"2023-04-14T22:01:44","date_gmt":"2023-04-14T22:01:44","guid":{"rendered":"https:\/\/epitomestaging.com\/tnc\/?page_id=11203"},"modified":"2024-07-26T17:12:18","modified_gmt":"2024-07-26T17:12:18","slug":"spinal-muscular-atrophy","status":"publish","type":"page","link":"https:\/\/epitomestaging.com\/tnc\/advocacy-partners\/spinal-muscular-atrophy\/","title":{"rendered":"Spinal Muscular Atrophy"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Home 2 Content Pg&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; background_image=&#8221;https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/02\/rsz-tnc-header-engagement-1000&#215;200-1.jpg&#8221; background_size=&#8221;initial&#8221; width_phone=&#8221;auto&#8221; width_last_edited=&#8221;off|desktop&#8221; max_width_last_edited=&#8221;off|desktop&#8221; module_alignment=&#8221;center&#8221; min_height_tablet=&#8221;300px&#8221; min_height_last_edited=&#8221;off|desktop&#8221; height=&#8221;200px&#8221; height_tablet=&#8221;154px&#8221; height_phone=&#8221;100px&#8221; height_last_edited=&#8221;on|phone&#8221; max_height_tablet=&#8221;300px&#8221; max_height_phone=&#8221;300px&#8221; max_height_last_edited=&#8221;off|desktop&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; top_divider_height_tablet=&#8221;&#8221; top_divider_height_phone=&#8221;50px&#8221; top_divider_height_last_edited=&#8221;on|phone&#8221; bottom_divider_style=&#8221;curve&#8221; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;70px&#8221; bottom_divider_arrangement=&#8221;above_content&#8221; bottom_divider_height_tablet=&#8221;70px&#8221; bottom_divider_height_phone=&#8221;50px&#8221; bottom_divider_height_last_edited=&#8221;on|desktop&#8221; background_last_edited=&#8221;on|tablet&#8221; background_image_phone=&#8221;https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/02\/rsz-tnc-mobile-stars.jpg&#8221; background_enable_image_phone=&#8221;on&#8221; parallax_tablet=&#8221;off&#8221; parallax_phone=&#8221;off&#8221; background_size_tablet=&#8221;contain&#8221; background_size_phone=&#8221;initial&#8221; background_position_tablet=&#8221;top_center&#8221; background_position_phone=&#8221;top_right&#8221; background_enable_video_mp4_tablet=&#8221;off&#8221; background_enable_video_mp4_phone=&#8221;off&#8221; module_alignment_tablet=&#8221;right&#8221; module_alignment_phone=&#8221;left&#8221; module_alignment_last_edited=&#8221;off|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text content_tablet=&#8221;<\/p>\n<h1>Patient Engagement<\/h1>\n<p>&#8221; content_phone=&#8221;<\/p>\n<h1>Patient Engagement<\/h1>\n<p>&#8221; content_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; z_index=&#8221;10&#8243; custom_margin=&#8221;30px||||false|false&#8221; custom_margin_tablet=&#8221;30px||||false|false&#8221; custom_margin_phone=&#8221;|0%|||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;|187px|||false|false&#8221; custom_padding_tablet=&#8221;|427px|||false|false&#8221; custom_padding_phone=&#8221;|0px|||false|false&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h1>For Patients<\/h1>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; custom_margin=&#8221;20px||21px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Partnership for Spinal Muscular Atrophy (SMA)<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;sma&#8221; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#ededed&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;40px||2px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_4,3_4&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.20.2&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|0px|30px|0px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/02\/logo-cure-sma-400X296.png&#8221; alt=&#8221;CureSMA Logo&#8221; title_text=&#8221;logo-cure-sma-400X296&#8243; url=&#8221;https:\/\/www.curesma.org\/&#8221; url_new_window=&#8221;on&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;0c026c7a-5762-4696-9e59-ca7bc7f580ed&#8221; max_width=&#8221;50%&#8221; max_width_tablet=&#8221;25%&#8221; max_width_phone=&#8221;50%&#8221; max_width_last_edited=&#8221;on|desktop&#8221; module_alignment=&#8221;center&#8221; module_alignment_tablet=&#8221;left&#8221; module_alignment_phone=&#8221;left&#8221; module_alignment_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>CureSMA<\/h3>\n<p>CureSMA funds and directs research paving the way for treatment and care for those affected by spinal muscular atrophy, while also promoting a supportive community. Through collaborative endeavors between researchers, practitioners, families, and the patients themselves, CureSMA takes a comprehensive approach to their strategy of developing a treatment.<\/p>\n<p class=\"learn-more\"><a href=\"https:\/\/www.curesma.org\/\" target=\"_blank\" rel=\"noopener\">LEARN MORE &gt;<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_id=&#8221;mda&#8221; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#ededed&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px||0px||true|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; custom_margin=&#8221;0px|auto||auto|false|false&#8221; custom_padding=&#8221;20px|30px|0px|30px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; text_letter_spacing=&#8221;6px&#8221; custom_margin=&#8221;||16px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>CLINICAL TRIAL<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"trial\"><a href=\"https:\/\/www.childrenshospital.org\/programs\/spinal-muscular-atrophy-program\" target=\"_blank\" rel=\"noopener\">Learn More &gt;<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; custom_margin=&#8221;0px|auto|10px|auto|false|false&#8221; custom_padding=&#8221;0px|30px|30px|30px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#0C71C3&#8243; custom_margin=&#8221;||-2px|||&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover_enabled=&#8221;on|hover&#8221; link_text_color__hover=&#8221;#FFFFFF&#8221;]<\/p>\n<h3>Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy (DEVOTE)<\/h3>\n<p>PI: Basil Darras, MD\u00a0 |\u00a0 Clinical Drug Trial \u2014 <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04089566\"> NCT04089566 &gt;<\/a><br \/>Patient Advocacy Group Partners: <a href=\"https:\/\/www.curesma.org\/\" target=\"_blank\" rel=\"noopener\">Cure SMA<\/a>, <a href=\"https:\/\/www.mda.org\/\" target=\"_blank\" rel=\"noopener\">Muscular Dystrophy Association<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; custom_margin=&#8221;30px|auto||auto|false|false&#8221; custom_padding=&#8221;20px|30px|0px|30px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; text_letter_spacing=&#8221;6px&#8221; custom_margin=&#8221;||16px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>CLINICAL TRIAL<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"trial\"><a href=\"https:\/\/www.childrenshospital.org\/programs\/spinal-muscular-atrophy-program\" target=\"_blank\" rel=\"noopener\">Learn More &gt;<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; custom_margin=&#8221;0px|auto|10px|auto|false|false&#8221; custom_padding=&#8221;0px|30px|30px|30px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#0C71C3&#8243; custom_margin=&#8221;||-2px|||&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover=&#8221;#FFFFFF&#8221; link_text_color__hover_enabled=&#8221;on|hover&#8221;]<\/p>\n<h3>Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA) (SMART)<\/h3>\n<p>PI: Basil Darras, MD\u00a0 |\u00a0 Clinical Drug Trial \u2014 <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04851873\"> NCT04851873 &gt;<\/a><br \/>\nPatient Advocacy Group Partners: <a href=\"https:\/\/www.curesma.org\/\" target=\"_blank\" rel=\"noopener\">Cure SMA<\/a>, <a href=\"https:\/\/www.mda.org\/\" target=\"_blank\" rel=\"noopener\">Muscular Dystrophy Association<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; custom_margin=&#8221;30px|auto||auto|false|false&#8221; custom_padding=&#8221;20px|30px|0px|30px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; text_letter_spacing=&#8221;6px&#8221; custom_margin=&#8221;||16px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>CLINICAL TRIAL<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"trial\"><a href=\"https:\/\/www.childrenshospital.org\/programs\/spinal-muscular-atrophy-program\" target=\"_blank\" rel=\"noopener\">Learn More &gt;<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; custom_margin=&#8221;0px|auto|10px|auto|false|false&#8221; custom_padding=&#8221;0px|30px|30px|30px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#0C71C3&#8243; custom_margin=&#8221;||-2px|||&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover=&#8221;#FFFFFF&#8221; link_text_color__hover_enabled=&#8221;on|hover&#8221;]<\/p>\n<h3>Investigate Safety, Tolerability, PK, PD and Efficacy of Risdiplam (RO7034067) in Infants With Type1 Spinal Muscular Atrophy (FIREFISH)<\/h3>\n<p>PI: Basil Darras, MD\u00a0 |\u00a0 Clinical Drug Trial \u2014 <a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02913482\"> NCT02913482 &gt;<\/a><br \/>\nPatient Advocacy Group Partners: <a href=\"https:\/\/www.curesma.org\/\" target=\"_blank\" rel=\"noopener\">Cure SMA<\/a>, <a href=\"https:\/\/www.mda.org\/\" target=\"_blank\" rel=\"noopener\">Muscular Dystrophy Association<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; custom_margin=&#8221;30px|auto||auto|false|false&#8221; custom_padding=&#8221;20px|30px|0px|30px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; text_letter_spacing=&#8221;6px&#8221; custom_margin=&#8221;||16px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>CLINICAL TRIAL<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;0px||0px||false|false&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"trial\"><a href=\"https:\/\/www.childrenshospital.org\/programs\/spinal-muscular-atrophy-program\" target=\"_blank\" rel=\"noopener\">Learn More &gt;<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#bbe4ed&#8221; custom_margin=&#8221;0px|auto|10px|auto|false|false&#8221; custom_padding=&#8221;0px|30px|30px|30px|false|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.19.2&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#0C71C3&#8243; custom_margin=&#8221;||-2px|||&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221; link_text_color__hover=&#8221;#FFFFFF&#8221; link_text_color__hover_enabled=&#8221;on|hover&#8221;]<\/p>\n<h3>A Study of Risdiplam (RO7034067) in Adult and Pediatric Participants With Spinal Muscular Atrophy (Jewelfish)<\/h3>\n<p>PI: Basil Darras, MD\u00a0 |\u00a0 Clinical Drug Trial \u2014 <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03032172\"> NCT03032172 &gt;<\/a><br \/>\nPatient Advocacy Group Partners: <a href=\"https:\/\/www.curesma.org\/\" target=\"_blank\" rel=\"noopener\">Cure SMA<\/a>, <a href=\"https:\/\/www.mda.org\/\" target=\"_blank\" rel=\"noopener\">Muscular Dystrophy Association<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; 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Through collaborative endeavors between researchers, practitioners, families, and the patients themselves, CureSMA takes a comprehensive approach to their strategy of developing a treatment. 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