[et_pb_section fb_built=”1″ admin_label=”Home 2 Content Pg” _builder_version=”4.16″ _module_preset=”default” background_color=”#bbe4ed” background_image=”https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/02\/rsz-tnc-header-scientists-1000×200-1.jpg” background_size=”initial” background_position=”top_center” width_phone=”auto” width_last_edited=”off|desktop” max_width_last_edited=”off|desktop” module_alignment=”center” min_height_tablet=”300px” min_height_last_edited=”off|desktop” height=”200px” height_tablet=”154px” height_phone=”100px” height_last_edited=”on|phone” max_height_tablet=”300px” max_height_phone=”300px” max_height_last_edited=”off|desktop” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” top_divider_height_tablet=”” top_divider_height_phone=”50px” top_divider_height_last_edited=”on|phone” bottom_divider_style=”curve” bottom_divider_color=”#FFFFFF” bottom_divider_height=”70px” bottom_divider_arrangement=”above_content” bottom_divider_height_tablet=”70px” bottom_divider_height_phone=”50px” bottom_divider_height_last_edited=”on|desktop” background_last_edited=”on|phone” background_image_phone=”https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/02\/rsz-tnc-mobile-stars.jpg” background_enable_image_phone=”on” parallax_tablet=”off” parallax_phone=”off” background_size_tablet=”contain” background_size_phone=”initial” background_position_tablet=”top_center” background_position_phone=”top_right” module_alignment_tablet=”right” module_alignment_phone=”left” module_alignment_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”4.16″ _module_preset=”default” module_alignment=”center” custom_margin=”0px||||false|false” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” z_index=”10″ custom_margin=”30px||||false|false” custom_padding_tablet=”|433px|||false|false” custom_padding_phone=”|0px|||false|false” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_enable_color=”off” custom_margin=”20px||20px||false|false” custom_padding=”0px||0px||false|false” locked=”off” global_colors_info=”{}”][et_pb_row custom_padding_last_edited=”on|desktop” _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0|0px|false|false” custom_padding_tablet=”||15px||false|false” custom_padding_phone=”||15px||false|false” custom_css_main_element=”display: flex;” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.0″ _module_preset=”default” background_enable_color=”off” custom_css_main_element=”display: block;||float: left;” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=”on|desktop” _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0|0px|false|false” custom_padding_tablet=”||15px||false|false” custom_padding_phone=”||15px||false|false” custom_css_main_element=”display: flex;” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” background_enable_color=”off” custom_margin=”-34px||0px||false|false” custom_margin_tablet=”0px||||false|false” custom_margin_phone=”||||false|false” custom_margin_last_edited=”on|tablet” custom_padding=”0px||10px||false|false” custom_padding_tablet=”0px||0px||false|false” custom_padding_phone=”||0px||false|false” custom_padding_last_edited=”on|phone” text_orientation_last_edited=”off|desktop” custom_css_main_element=”float:right;” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”float:none;” custom_css_main_element_phone=”float:none;”]<\/p>\n
Cite the Core ><\/a><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_enable_color=”off” custom_margin=”||30px||false|false” custom_padding=”0px||0px||false|false” locked=”off” global_colors_info=”{}”][et_pb_row use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.22.0″ _module_preset=”default” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n Human Neuron Core ><\/a> Clinical Neurophysiology Research Core ><\/a>Clinical Research Operations Core ><\/a> Translational Genomic Medicine Core ><\/a> Medicinal Chemistry Core ><\/a>Data Organization Collaboration Service ><\/a><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”HNC” _builder_version=”4.21.0″ _module_preset=”default” background_color=”#ededed” custom_margin=”||50px||false|false” custom_padding=”25px|0px|25px|0|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#e02b20″ header_2_text_color=”#0c859e” custom_margin=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/05\/HNC2.jpg” alt=”HNC Researchers” title_text=”HNC2″ _builder_version=”4.17.3″ _module_preset=”_initial” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_margin=”||8px||false|false” custom_padding=”||0px||false|false” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_line_height=”1.2em” custom_margin=”0px||10px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n Mustafa Sahin, MD, PhD Elizabeth Buttermore, PhD Lee Barrett, PhD Cidi Chen, PhD Dosh Whye, MS Grazia Iannello, PhD<\/span><\/strong> Gayathri Rajaram-Srinivasan, PhD<\/span><\/strong> Erika Norabuena<\/strong> Taryn Polanco Becca Lewis<\/strong> Ryan Guardado Remi Hirsh [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” custom_margin=”40px||10px||false|false” custom_padding=”0px||0px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_margin=”0px||1px||false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n TNC@childrens.harvard.edu. <\/a> [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” custom_margin=”40px||10px||false|false” custom_padding=”0px||0px||false|false” border_width_bottom=”1px” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_padding=”0px||||false|false” global_colors_info=”{}”]<\/p>\n \u00a0iLab Login ><\/a><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_padding=”0px||||false|false” global_colors_info=”{}”]<\/p>\n Request Our Services ><\/a><\/p>\n Service requests are reviewed monthly.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_align=”left” custom_margin=”0px||0px||true|false” custom_padding=”0px||0px||true|false” global_colors_info=”{}”]<\/p>\n The Human Neuron Core is a state-of-the-art facility for disease modeling in human neurons derived from patients. We draw on the expertise of a community of researchers in developmental neuroscience, neurology and stem cell science to support preclinical assay development and to screen for potential therapeutics.<\/span><\/p>\n Equipment<\/strong><\/p>\n Services<\/strong><\/p>\n The Human Neuron Core hosts a Repository for Neurological Disorders. The Repository is a data and biological specimen bank that pairs biological samples (including DNA, RNA, cerebral spinal fluid, brain tissue, and serum) with phenotypic data for translational research and clinical trials. Sample collections are available for fellowship projects through an application process.\u00a0<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”CNRC” _builder_version=”4.22.2″ _module_preset=”default” background_color=”#ededed” custom_margin=”||50px||false|false” custom_padding=”25px|0px|25px|0|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#e02b20″ header_2_text_color=”#0c859e” custom_margin=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2024\/11\/CNRC-Website-Picture-Option-1-Cropped-300×300-1.jpg” title_text=”CNRC Website Picture Option 1 – Cropped” _builder_version=”4.22.1″ _module_preset=”_initial” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_margin=”||8px||false|false” custom_padding=”||0px||false|false” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n April Levin, MD<\/strong> Jeff Gavornik, PhD<\/strong> Catherine Serianni, MPH<\/strong> [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||0px|||” locked=”off” global_colors_info=”{}”]<\/p>\n Request Our Services ><\/a><\/p>\n Service requests are reviewed monthly.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n The Clinical Neurophysiology Research Core (CNRC) aims to become a leader in the acquisition and analysis of high-quality human neurophysiological data to reflect neural circuit integrity in neurologic disease and developmental disorders. The CNRC occupies a purpose-built space at the Brain, Mind & Behavior Center at Two Brookline Place, and is outfitted with several new NIH-funded, high density electrophysiology systems that provides integration with stimulus presentation, eye tracking, transcranial magnetic stimulation (TMS), and magnetic resonance imaging (MRI). The Core also utilizes a customized platform for high-throughput electroencephalography (EEG) data analysis.<\/p>\n Clinical Services:<\/strong><\/p>\n Consultation services:<\/strong><\/p>\n We also act as a conduit to the Epilepsy Monitoring Unit led by Dr. Alexander Rotenberg and interface with the Research Imaging Core led by Dr. Simon Warfield for imaging-based biomarker acquisition.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”CROC” _builder_version=”4.22.2″ _module_preset=”default” background_color=”#ededed” custom_margin=”||50px||false|false” custom_padding=”25px|0px|25px|0|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#e02b20″ header_2_text_color=”#0c859e” custom_margin=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/02\/hanson-photo-mp-750×878-1.jpg” title_text=”hanson-photo-mp-750×878″ _builder_version=”4.16″ _module_preset=”_initial” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_margin=”||8px||false|false” custom_padding=”||0px||false|false” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_line_height=”1.2em” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n Stephanie Jo Brewster, MS, CGC Celia Tam, PhD Abby Donaghue, MA Izzi Byrne, MA<\/b> Charles A. Nelson, PhD <\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||0px|||” locked=”off” global_colors_info=”{}”]<\/p>\n Request Our Services ><\/a><\/p>\n Service requests are reviewed monthly.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n The Clinical Research Operations Core collaborates with investigators to plan and implement translational research through each stage of the drug discovery pipeline \u2014 from study design to regulatory submissions.<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Our team includes clinical research managers, genetic counselors, research nurses, regulatory specialists and study coordinators with expertise in protocol development, regulatory policy, study start-up and project execution. We offer regulatory guidance, study-staff training, project management support and study recruitment assistance for a variety of clinical research projects, including preclinical to phase 2 clinical trials, biomarker, and outcome studies.<\/p>\n Services provided:<\/strong><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”]<\/p>\n The Human Neurobehavioral Core Service (HNBCS) develops and provides behavioral assessment resources for translational neuroscience research at Boston Children\u2019s Hospital. The Service was established through a collaboration between the Neurodevelopmental Disorders Phenotyping Program and Laboratories of Cognitive Neuroscience in the Division of Developmental Medicine and the Clinical Behavioral Science Core in the Department of Psychiatry and Behavioral Sciences.<\/p>\n We offer the consulting services of senior research psychologists with expertise in the development, administration and analysis of neurobehavioral assessments from birth through adulthood. \u00a0A supervising clinical psychologist and research assistants are available to support clinical research including clinical trial execution. Our staff is trained to administer numerous measures including adaptive, behavioral, language and cognitive testing to families with a variety of neurodevelopmental disorders as well as individuals who are typically developing.<\/p>\n We provide:<\/strong><\/p>\n The Human Neurobehavioral Core Service is a collaboration between the Rosamund Stone Zander Translational Neuroscience Center and the Division of the Developmental Medicine.<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n We manage a Research Participation Registry of more than 30,000 individuals (children and adults) with typical and atypical development who have expressed interest in research participation. The Registry serves as a vital recruitment resource for investigators enrolling individuals of all ages with neurodevelopmental challenges as well as those who are typically developing.<\/p>\n The Research Participant Registry is a collaboration between the Rosamund Stone Zander Translational Neuroscience Center and the Division of the Developmental Medicine at Boston Children\u2019s Hospital.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”TGMC” _builder_version=”4.22.2″ _module_preset=”default” background_color=”#ededed” custom_margin=”||50px||false|false” custom_padding=”25px|0px|25px|0|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#e02b20″ header_2_text_color=”#0c859e” custom_margin=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/02\/rsz-tnc-microarray-imaging.jpg” title_text=”FPO-istockphoto-515453393-mp” _builder_version=”4.16″ _module_preset=”_initial” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_margin=”||8px||false|false” custom_padding=”||0px||false|false” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_line_height=”1.2em” border_width_bottom=”1px” border_color_bottom=”#000000″ locked=”off” global_colors_info=”{}”]<\/p>\n Maya Chopra, MBBS, FRACP Raymond Belanger Deloge, MS, CGC Zo\u00eb Frazier, MS, CGC Abigail Sveden, MS, CGC Jillian O’Toole, MS, CGC Muhammed Cagri Bayraktutan, MD [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_line_height=”1.2em” border_width_bottom=”1px” border_color_bottom=”#000000″ locked=”off” global_colors_info=”{}”]<\/p>\n TGM@childrens.harvard.edu<\/a><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||0px|||” locked=”off” global_colors_info=”{}”]<\/p>\n Request Our Services ><\/a><\/p>\n Service requests are reviewed monthly.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Led by a Clinical Geneticist \/ Pediatrician, the expertise of the Translational Genomic Medicine (TGM) Core is at the intersection of clinical genetics, clinical bioinformatics, and translational medicine. We offer consultation and collaboration for both clinical and research initiatives focused on rare Mendelian neurodevelopmental disorders (NDDs) within Boston Children\u2019s Hospital as well as other institutions. The Core works closely with the other TNC cores to better delineate new genetic disorders, understand the underpinning mechanisms, and to evaluate the suitability of NDDs for gene-based therapeutic approaches.<\/p>\n We provide:<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”MCC” _builder_version=”4.22.2″ _module_preset=”default” background_color=”#ededed” custom_margin=”||50px||false|false” custom_padding=”25px|0px|25px|0|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16.1″ _module_preset=”default” header_text_color=”#e02b20″ header_2_text_color=”#0c859e” custom_margin=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/04\/beaker_dosh.jpg” alt=”TNC lab personnel” title_text=”beaker_dosh” _builder_version=”4.16.1″ _module_preset=”_initial” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_margin=”||8px||false|false” custom_padding=”||0px||false|false” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16.1″ _module_preset=”default” text_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n Jed Hubbs, PhD [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||0px|||” locked=”off” global_colors_info=”{}”]<\/p>\n Request Our Services ><\/a><\/p>\n Service requests are reviewed monthly.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Small molecule drug discovery is a process that integrates medicinal chemistry with other disciplines including cell biology and animal pharmacology. Successful drug optimization transforms a screening hit or tool compound to a drug candidate. This process requires parallel optimization of desired drug activity in preclinical disease, pharmacokinetic, and toxicological models.<\/p>\n The medicinal chemistry core provides consultation and services throughout the process, from small molecule library selection and sourcing to lead optimization and drug candidate selection. To maximize efficiency, experimental design, troubleshooting, and project management are performed within the Core, and chemical synthesis is typically conducted at a network of preferred contract research organizations. Depending on project complexity, these services can be conducted on a fee-for-service, percent effort plus costs, or collaborative basis.<\/p>\n Our services include:<\/strong><\/p>\n In the future, we aim to provide preclinical bioanalytical services and targeted protein quantification.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”DOCS” _builder_version=”4.22.2″ _module_preset=”default” background_color=”#ededed” custom_margin=”||50px||false|false” custom_padding=”25px|0px|25px|0|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#e02b20″ header_2_text_color=”#0c859e” custom_margin=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/epitomestaging.com\/tnc\/wp-content\/uploads\/2022\/02\/rsz-tnc-servers.jpg” alt=”RSZ TNC Servers” title_text=”rsz-tnc-servers” _builder_version=”4.16″ _module_preset=”_initial” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” custom_margin=”||8px||false|false” custom_padding=”||0px||false|false” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.20.2″ _module_preset=”default” text_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n Alexander Li Cohen, MD, PhD Zexia Lu, BA, MS Jiaqi Zhao, BS [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_line_height=”1.2em” custom_margin=”40px||10px||false|false” custom_padding=”0px||0px||false|false” border_width_bottom=”1px” locked=”off” global_colors_info=”{}”]<\/p>\n \n [\/et_pb_text][et_pb_text _builder_version=”4.20.2″ _module_preset=”default” text_line_height=”1.2em” header_3_font=”||||||||” min_height=”82.4px” custom_margin=”0px||1px||false|false” custom_padding=”0px||0px||false|false” locked=”off” global_colors_info=”{}”]<\/p>\n TNCDoCS@childrens.harvard.edu<\/a>\u00a0 [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||0px|||” locked=”off” global_colors_info=”{}”]<\/p>\nHuman Neuron Core<\/h2>\n
Staff<\/h3>\n
<\/strong>Director<\/em><\/p>\n
<\/strong>Associate Director<\/em><\/p>\n
<\/strong>Assistant Director,\u00a0Assay Development and Screening Facility<\/em><\/p>\n
<\/strong>Assistant Director, CRISPR Services<\/em><\/p>\n
<\/strong>Assistant Director, Differentiation Services<\/em><\/p>\n
<\/strong>Senior Staff Scientist and Assistant Director<\/em><\/p>\n
<\/strong>Staff Scientist<\/em><\/p>\n
<\/strong>Research Lab Manager<\/em><\/p>\n
<\/strong>Research Assistant<\/em><\/p>\n
<\/strong>Research Assistant<\/em><\/p>\n
<\/strong>Repository Research Coordinator<\/em><\/p>\n
<\/strong>Repository Research Coordinator<\/em><\/strong><\/p>\nRepository questions and project inquiries<\/h3>\n
Please allow up to two weeks for responses.<\/p>\nAccess iLab to schedule a service.<\/h3>\n
\n
\n
Repository<\/h3>\n
Clinical Neurophysiology Research Core<\/h2>\n
Staff<\/h3>\n
Core Director<\/em><\/p>\n
Scientific Director<\/em><\/p>\n
Scientific Operations Director<\/em><\/p>\n\n
\n
Clinical Research Operations Core<\/h2>\n
Staff<\/h3>\n
<\/strong>Director<\/em><\/p>\n
<\/b>Managing Director, Human Neurobehavioral Core Service<\/em><\/p>\n
<\/b>Clinical Research Specialist, Human Neurobehavioral Core Service<\/em><\/p>\n
<\/b>Clinical Research Coordinator, Human Neurobehavioral Core Service<\/em><\/p>\n
<\/strong>Director, Research Participant Registry<\/em><\/p>\nClinical Research and Regulatory Affairs Service<\/h3>\n
\n
Human Neurobehavioral Core Service<\/h3>\n
\n
Research Participation Registry<\/h3>\n
Translational Genomic Medicine Core<\/h2>\n
Staff<\/h3>\n
<\/strong>Director<\/em><\/p>\n
<\/strong>Translational Genomic Medicine Specialist<\/em>
<\/strong><\/p>\n
<\/strong>Translational Genomic Medicine Specialist<\/em><\/p>\n
<\/strong>Translational Genomic Medicine Specialist<\/em><\/strong><\/p>\n
<\/strong>Translational Genomic Medicine Specialist<\/em><\/p>\n
<\/strong>Clinical Research Fellow<\/em><\/p>\n\n
Medicinal Chemistry Core<\/h2>\n
Staff<\/h3>\n
<\/strong>Director<\/em><\/p>\n\n
Data Organization Collaboration Service<\/h2>\n
Staff<\/h3>\n
<\/strong>Director<\/em><\/p>\n
<\/strong>Data Manager<\/em><\/p>\n
<\/b>Data Manager
<\/em><\/p>\nService inquiries<\/h3>\n
Please allow up to two weeks for responses.<\/p>\n